منابع مشابه
Deamination of Serine
In an investigation of transamination reactions between pyridoxal and amino acids at 100” (2) serine was found to behave anomalously, apparently being deaminated to pyruvic acid with little change in pyridoxal concentration. Although serine is known to be deaminated by hot concentrated alkalies (3) and acids (4), such a non-enzymatic reaction in the pH range near neutrality has not been reporte...
متن کاملThe Enzymatic Deamination of Amphetamine
A previous st,udy on the metabolism of amphetamine (1-phenyl-2-aminopropane), widely used as a stimulant of the central nervous system, showed that its major route of biotransformation in the rat and dog involved hydroxylation of the aromatic ring. In the rabbit, however, the compound was not hydroxylated, but was found to be transformed in another manner (2). The present report describes an en...
متن کاملNitrosative cytosine deamination. An exploration of the chemistry emanating from deamination with pyrimidine ring-opening.
A discussion of nitrosative deamination of cytosine 1 is presented that argues for the formation of 6 by diazotization of 1 to cytosinediazonium ion 2 and its electrostatic complex 3, dediazoniation to 4 <--> 5, and amide-bond cleavage to 6. The reaction channels available to 6 include hydrolytic deglycation to 3-isocyanatoacrylonitrile 7, water addition to carbamic acid 9 with the possibility ...
متن کاملHomoserine Dehydrogenase of Rhodospirillum rubrum
Homoserine dehydrogenase catalyzes the reductive conversion of aspartate P-semialdehyde to homoserine (l), which has been identified in several microorganisms as a precursor of three other amino acids. On the one hand, homoserine is converted to methionine, and through a separate sequence of reactions is transformed to threonine, a precursor of isoleucine (2). Recent studies (3-7) have provided...
متن کاملHomoserine Dehydrsgenase of Rhodospirillum rubrum
Homoserine dehydrogenase of Rhodospirillum rubrum has been purified by heat treatment, ammonium sulfate fractionation, and by two successive gel filtration steps on Sephadex G-ZOO in the absence and presence of L-threonine, an allosteric inhibitor. The pure protein is free of aspartokinase and aspartate /?-semialdehyde dehydrogenase activities. From the sedimentation velocity centrifugation and...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1950
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56379-1